iPod - icariin role of the cardiovascular system lieu5ft1 - Sun Nov 25, 2012 6:55 am Post subject: icariin role of the cardiovascular system
icariin role of the cardiovascular system
Isolated rabbit heart perfusion experiments prove: icariin and Epimedium leaching solution and from 200% non-amino acid portion of the water extract film extract showed a significant increase in coronary flow in isolated rabbit hearts.
200% icariin 60 decoction the 0.5ml give away the perfused guinea pig heart, their coronary flow increased by an average of 126.6%.Intravenously to dogs from Epimedium extract non-amino acid, coronary flow can significantly increase, and a significant reduction in coronary resistance, but had no significant effect on the heart. The anesthetized rabbits intravenous injection of non-amino acid 1g/kg after the performance is over to reduce the role of left ventricular diastolic blood pressure, and can temporarily reduce left ventricular diastolic pressures, but the role is weak. icariin 50 non-amino acid part has a protective effect on acute myocardial ischemia caused by pituitrin experimental guinea pigs of the poisonous hairs spin Hanako glycosides K and epinephrine arrhythmias, although not completely confrontation, but obviously shorten its duration.
Epimedium Flavonoids can improve hypoxia tolerance; slow down the rat heart rate, and speed up the heart rate effect against isoproterenol; increase coronary blood flow in isolated rabbit hearts; and the central inhibition effect and weak antiarrhythmic effect.
The icariin perfusion on toads reign or isolated heart, significantly enhanced myocardial contractility; artificial heart failure caused by sodium pentobarbital toad, also its myocardial tension recovery.Icariin to rabbits intravenously, significantly increased myocardial tension, the effect can be maintained for several hours . Animal experiments showed that: The icariin and decoction ethanol leaching solution intravenously in the cats, rabbits and rats, have antihypertensive effect. The most obvious of which the role of rabbit. The Epimedium methanol extract 10g/kg to the renal hypertensive rats fed, hypotensive effect .
There are reports that icariin can be blocked a rabbit bilateral carotid artery caused by pressurized reflection, but not block the pressor effect of norepinephrine. Cat after injection of atropine, the goods are still antihypertensive effect without significantly weakening its strength, but can inhibit the sympathetic preganglionic fibers of electrical stimulation of the cat nictitating membrane induced contractile responses were not suppressed, while the response to electrical stimulation of postganglionic fibers role.Therefore believe that Icariin hypotensive effect of adrenergic alpha-receptors and is independent of the M-cholinergic system, mainly sympathetic ganglion block related .but also report that icariin endogenous catecholamine antagonism has excitatory effects of beta-receptor.